The tractor-trailer crashed in the northbound lanes of I-81, near Exit 80/Route 743 for Grantville around 1 a.m. on Sept. 1, authorities say.
The Pennsylvania State Police, fire police, and the Grantville Volunteer Fire Company were called to the scene.
The highway reopened around 4:30 a.m., according to PennDOT.
It is unclear how many vehicles were involved or if any injuries were reported. Check back here for those and any other updates.
Click here to follow Daily Voice Lancaster and receive free news updates.